Journal article
Gas-chromatographic analysis for valproic acid as phenacyl esters.
Abstract
We describe a novel isothermal gas-chromatographic procedure for measuring valproic acid. Plasma, with cyclohexanecarboxylic acid added as internal standard, is selectively extracted with pentane to minimize the extraction of other acidic drugs. To convert carboxylic acids to their phenacyl esters, alpha-bromoacetophenone is added to the organic extract before evaporating the solvent. These esters are relatively less volatile than the acids …
Authors
Gupta RN; Eng F; Gupta ML
Journal
Clinical Chemistry, Vol. 25, No. 7, pp. 1303–1305
Publisher
Oxford University Press (OUP)
Publication Date
July 1, 1979
DOI
10.1093/clinchem/25.7.1303
ISSN
0009-9147