Journal article
Estimation of maprotiline in serum by gas-chromatography, with use of a nitrogen-specific detector.
Abstract
We describe a gas-chromatographic procedure for estimating therapeutic concentrations of maprotiline, a new tetracyclic antidepressant, in serum by use of a nitrogen-specific detector. Desmethyldoxepin, a secondary amine similar in structure to maprotiline, is added as a mass internal standard to the specimen before extraction, to obviate the need for accurate measurements of volumes during extraction and analysis. Both maprotiline and the …
Authors
Gupta RN; Molnar G; Gupta ML
Journal
Clinical Chemistry, Vol. 23, No. 10, pp. 1849–1852
Publisher
Oxford University Press (OUP)
Publication Date
October 1, 1977
DOI
10.1093/clinchem/23.10.1849
ISSN
0009-9147