Training Response in Patients With Coronary Artery Disease Receiving β-Adrenergic Blocking Drugs With or Without Partial Agonist Activity

It has been suggested that beta-adrenoceptor blocking agents may impair the training response but that this may not occur if the agent possesses partial agonist activity (PAA). We tested these hypotheses in 39 male patients, following myocardial infarction or coronary artery bypass graft surgery, who underwent structured exercise training three times a week for 8 weeks. Exercise tolerance was assessed before training, within 5 days after …