Journal article
Role of STAT6 and SMAD2 in a model of chronic allergen exposure: a mouse strain comparison study
Abstract
BACKGROUND: Asthma is a disease characterized by variable and reversible airway obstruction and is associated with airway inflammation, airway remodelling (including goblet cell hyperplasia, increased collagen deposition and increased smooth muscle mass) and increased airway responsiveness. It is believed that airway inflammation plays a critical role in the development of airway remodelling, with IL-13 and TGF-beta1 pathways being strongly …
Authors
Hirota JA; Ask K; Fritz D; Ellis R; Wattie J; Richards CD; Labiris R; Kolb M; Inman MD
Journal
Clinical & Experimental Allergy, Vol. 39, No. 1, pp. 147–158
Publisher
Wiley
Publication Date
1 2009
DOI
10.1111/j.1365-2222.2008.03109.x
ISSN
0954-7894