Journal article
A GABAergic system in airway epithelium is essential for mucus overproduction in asthma
Abstract
Abstractγ-Aminobutyric acid (GABA) is an important neurotransmitter that, through the subtype A GABA receptor (GABAAR), induces inhibition in the adult brain. Here we show that an excitatory, rather than inhibitory, GABAergic system exists in airway epithelial cells. Both GABAARs and the GABA synthetic enzyme glutamic acid decarboxylase (GAD) are expressed in pulmonary epithelial cells. Activation of GABAARs depolarized these cells. The …
Authors
Xiang Y-Y; Wang S; Liu M; Hirota JA; Li J; Ju W; Fan Y; Kelly MM; Ye B; Orser B
Journal
Nature Medicine, Vol. 13, No. 7, pp. 862–867
Publisher
Springer Nature
Publication Date
7 2007
DOI
10.1038/nm1604
ISSN
1078-8956