Journal article
Human Cytochrome P450 Liability Studies of trans-Dihydronarciclasine: A Readily Available, Potent, and Selective Cancer Cell Growth Inhibitor
Abstract
The cytochrome P45O activities of the naturally occurring Amaryllidaceae alkaloid narciclasine (3), isolated from Narcissus pseudonarcissus, and synthetic derivative trans-dihydronarciclasine (5) are reported. While narciclasine was found to possess potent inhibitory activity to human CYP3A4, its dihydro analogue was inactive. This study revealed that the C1-C10b double bond is required for inhibition of this crucial metabolizing enzyme. …
Authors
McNulty J; Thorat A; Vurgun N; Nair JJ; Makaji E; Crankshaw DJ; Holloway AC; Pandey S
Journal
Journal of Natural Products, Vol. 74, No. 1, pp. 106–108
Publisher
American Chemical Society (ACS)
Publication Date
January 28, 2011
DOI
10.1021/np100657w
ISSN
0163-3864