Journal article
Insulin, Insulin-like Growth Factor-I, and Platelet-Derived Growth Factor Activate Extracellular Signal-Regulated Kinase by Distinct Pathways in Muscle Cells
Abstract
We have investigated the signaling pathways initiated by insulin, insulin-like growth factor-1 (IGF-I), and platelet-derived growth factor (PDGF) leading to activation of the extracellular signal-regulated kinase (ERK) in L6 myotubes. Insulin but not IGF-I or PDGF-induced ERK activation was abrogated by Ras inhibition, either by treatment with the farnesyl transferase inhibitor FTP III, or by actin disassembly by cytochalasin D, previously …
Authors
Tsakiridis T; Tsiani E; Lekas P; Bergman A; Cherepanov V; Whiteside C; Downey GP
Journal
Biochemical and Biophysical Research Communications, Vol. 288, No. 1, pp. 205–211
Publisher
Elsevier
Publication Date
10 2001
DOI
10.1006/bbrc.2001.5762
ISSN
0006-291X
Fields of Research (FoR)
Medical Subject Headings (MeSH)
ActinsAnimalsCalcium-Calmodulin-Dependent Protein KinasesCell LineCytoskeletonEnzyme InhibitorsGlycogen Synthase Kinase 3Glycogen Synthase KinasesInsulinInsulin-Like Growth Factor IMAP Kinase Signaling SystemMitogen-Activated Protein Kinase KinasesMitogen-Activated Protein KinasesMuscle, SkeletalOrganophosphonatesPhosphatidylinositol 3-KinasesPhosphorylationPlatelet-Derived Growth FactorProtein Kinase CProtein Serine-Threonine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-aktProto-Oncogene Proteins p21(ras)