Journal article
Reaction of N-methyl-N′-nitro-N-nitroguanidine and N-methyl-N-nitroso-p-Toluenesulfonamide with DNA in vitro
Abstract
Radioactivity from N-[14C]methyl-N′-nitro-N-nitrosoguanidine or N-[14C]methyl-N-nitroso-p-toluenesulfonamide is incorporated into DNA in vitro. The principal product formed is 7-methylguanine. The extent of methylation of DNA by both these agents increases with increasing OH− concentration. Methylation by N-[14C]methyl-N′-nitro-N-nitrosoguanidine is increased by the presence of a thiol while methylation by …
Authors
McCalla DR
Journal
Biochimica et Biophysica Acta, Vol. 155, No. 1, pp. 114–120
Publisher
Elsevier
Publication Date
1 1968
DOI
10.1016/0005-2787(68)90341-9
ISSN
0006-3002