Journal article
Glucosamine induces ER stress by disrupting lipid-linked oligosaccharide biosynthesis and N-linked protein glycosylation
Abstract
Glucosamine is an essential substrate for N-linked protein glycosylation. However, elevated levels of glucosamine can induce endoplasmic reticulum (ER) stress. Glucosamine-induced ER stress has been implicated in the development of diabetic complications, including atherosclerosis and hepatic steatosis. In this study, we investigate the potential relationship between the effects of glucosamine on lipid-linked oligosaccharide (LLO) biosynthesis, …
Authors
Beriault DR; Dang VT; Zhong LH; Petlura CI; McAlpine CS; Shi Y; Werstuck GH
Journal
AJP Endocrinology and Metabolism, Vol. 312, No. 1, pp. e48–e57
Publisher
American Physiological Society
Publication Date
January 1, 2017
DOI
10.1152/ajpendo.00275.2016
ISSN
0193-1849