Journal article
BCL-2: the pendulum of the cell fate.
Abstract
The homeostasis of normal tissues is a balance between cell proliferation and cell death. Alterations of both pathways contribute to a clonal expansion of cancer cells. Bcl-2 and its family play an important role in the regulation of the apoptotic pathway. Apoptosis or programmed cell death is an active form of cell suicide that is characterized by specific morphological and biochemical events. These include cleavege of genomic DNA into …
Authors
Blandino G; Strano S
Journal
Journal of Experimental & Clinical Cancer Research, Vol. 16, No. 1, pp. 3–10
Publication Date
March 1997
ISSN
0392-9078
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsApoptosisCarrier ProteinsDNA-Binding ProteinsGene Expression Regulation, NeoplasticGenes, bcl-2Homeodomain ProteinsHumansLymphoma, FollicularMembrane ProteinsMiceMinor Histocompatibility AntigensMyeloid Cell Leukemia Sequence 1 ProteinNeoplasm ProteinsNeoplasmsProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2Replication Protein CRepressor ProteinsSaccharomyces cerevisiae ProteinsTranscription Factorsbcl-2 Homologous Antagonist-Killer Proteinbcl-2-Associated X Proteinbcl-Associated Death Protein