Proteins trapped in porous silica: Biomaterials scaffolds

The entrapment of proteins to observe the performance of their biological function in highly porous silica was discussed. It was found that silica could form as a support that is bioresponsive to its environment. It was observed that highly compatible, porous silica matrices could be readily prepared at ambient temperatures. Proteins could also be incorporated during the fabrication process and remain enzymatically active over extended periods of time. The results show that silica morphology could be readily controlled by changing the chemical nature of the dopant.