Journal article
Compendium of TCDD-mediated transcriptomic response datasets in mammalian model systems
Abstract
Background2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is the most potent congener of the dioxin class of environmental contaminants. Exposure to TCDD causes a wide range of toxic outcomes, ranging from chloracne to acute lethality. The severity of toxicity is highly dependent on the aryl hydrocarbon receptor (AHR). Binding of TCDD to the AHR leads to changes in transcription of numerous genes. Studies evaluating the transcriptional changes …
Authors
Prokopec SD; Houlahan KE; Sun RX; Watson JD; Yao CQ; Lee J; P’ng C; Pang R; Wu AH; Chong LC
Journal
BMC Genomics, Vol. 18, No. 1,
Publisher
Springer Nature
Publication Date
December 2017
DOI
10.1186/s12864-016-3446-z
ISSN
1471-2164