Journal article
Therapeutic strategies for thrombosis: new targets and approaches
Abstract
Antiplatelet agents and anticoagulants are a mainstay for the prevention and treatment of thrombosis. However, despite advances in antithrombotic therapy, a fundamental challenge is the side effect of bleeding. Improved understanding of the mechanisms of haemostasis and thrombosis has revealed new targets for attenuating thrombosis with the potential for less bleeding, including glycoprotein VI on platelets and factor XIa of the coagulation …
Authors
Mackman N; Bergmeier W; Stouffer GA; Weitz JI
Journal
Nature Reviews Drug Discovery, Vol. 19, No. 5, pp. 333–352
Publisher
Springer Nature
Publication Date
May 2020
DOI
10.1038/s41573-020-0061-0
ISSN
1474-1776