Journal article
Rivaroxaban and Dabigatran for Suppression of Mechanical Heart Valve–Induced Thrombin Generation
Abstract
BACKGROUND: Patients with mechanical heart valves (MHVs) require warfarin to prevent thromboembolism. Dabigatran was less effective than warfarin in patients with MHVs, which prompted a black box warning against the use of direct oral anticoagulants for this indication. However, rivaroxaban and apixaban, which inhibit factor Xa, have not been evaluated in patients with MHVs. To determine whether rivaroxaban and apixaban would be effective, we …
Authors
Jaffer IH; Fredenburgh JC; Stafford A; Whitlock RP; Weitz JI
Journal
The Annals of Thoracic Surgery, Vol. 110, No. 2, pp. 582–590
Publisher
Elsevier
Publication Date
8 2020
DOI
10.1016/j.athoracsur.2019.10.091
ISSN
0003-4975