NOX4-driven ROS formation mediates PTP...

Abstract

Activating mutations of FMS-like tyrosine kinase 3 (FLT3), notably internal tandem duplications (ITDs), are associated with a grave prognosis in acute myeloid leukemia (AML). Transforming FLT3ITD signal transduction causes formation of reactive oxygen species (ROS) and inactivation of the protein-tyrosine phosphatase (PTP) DEP-1/PTPRJ, a negative regulator of FLT3 signaling. Here we addressed the underlying mechanisms and biological …

Authors

Jayavelu AK; Müller JP; Bauer R; Böhmer S-A; Lässig J; Cerny-Reiterer S; Sperr WR; Valent P; Maurer B; Moriggl R

Journal

Leukemia, Vol. 30, No. 2, pp. 473–483

Publisher

Springer Nature

Publication Date

February 2016

DOI

10.1038/leu.2015.234

ISSN

0887-6924

Associated Experts

Tobias Berg

Associate Professor, Faculty of Health Sciences

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Labels

Fields of Research (FoR)

32 Biomedical and Clinical Sciences 3201 Cardiovascular medicine and haematology 3202 Clinical sciences 3211 Oncology and carcinogenesis

Medical Subject Headings (MeSH)

Animals Cell Transformation, Neoplastic Cells, Cultured Humans Leukemia, Myeloid, Acute Mice Mice, Inbred C3H Mice, Inbred C57BL NADPH Oxidase 4 NADPH Oxidases Protein Tyrosine Phosphatases Reactive Oxygen Species Receptor-Like Protein Tyrosine Phosphatases, Class 3 Tandem Repeat Sequences fms-Like Tyrosine Kinase 3

NOX4-driven ROS formation mediates PTP inactivation and cell transformation in FLT3ITD-positive AML cells