Journal article
A CD133-AKT-Wnt signaling axis drives glioblastoma brain tumor-initiating cells
Abstract
Mechanistic insight into signaling pathways downstream of surface receptors has been revolutionized with integrated cancer genomics. This has fostered current treatment modalities, namely immunotherapy, to capitalize on targeting key oncogenic signaling nodes downstream of a limited number of surface markers. Unfortunately, rudimentary mechanistic understanding of most other cell surface proteins has reduced the clinical utility of these …
Authors
Manoranjan B; Chokshi C; Venugopal C; Subapanditha M; Savage N; Tatari N; Provias JP; Murty NK; Moffat J; Doble BW
Journal
Oncogene, Vol. 39, No. 7, pp. 1590–1599
Publisher
Springer Nature
Publication Date
February 13, 2020
DOI
10.1038/s41388-019-1086-x
ISSN
0950-9232