Journal article
Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity Associated Type 2 Diabetes
Abstract
In type 2 diabetes (T2D), hepatic insulin resistance is strongly associated with nonalcoholic fatty liver disease (NAFLD). In this study, we hypothesized that the DNA methylome of livers from patients with T2D compared with livers of individuals with normal plasma glucose levels can unveil some mechanism of hepatic insulin resistance that could link to NAFLD. Using DNA methylome and transcriptome analyses of livers from obese individuals, we …
Authors
Abderrahmani A; Yengo L; Caiazzo R; Canouil M; Cauchi S; Raverdy V; Plaisance V; Pawlowski V; Lobbens S; Maillet J
Journal
Diabetes, Vol. 67, No. 7,
Publisher
American Diabetes Association
Publication Date
July 1, 2018
DOI
10.2337/db17-1539
ISSN
0012-1797