Journal article
Filamin A regulates monocyte migration through Rho small GTPases during osteoclastogenesis
Abstract
Osteoclastogenesis (OCG) results from the fusion of monocytes after stimulation with macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-kappaB ligand (RANKL). Migration of monocytes into close proximity precedes critical fusion events that are required for osteoclast formation. Cellular migration requires leading-edge actin cytoskeleton assembly that drives cellular locomotion. Filamin A (FLNa) cross-links F-actin …
Authors
Leung R; Wang Y; Cuddy K; Sun C; Magalhaes J; Grynpas M; Glogauer M
Journal
Journal of Bone and Mineral Research, Vol. 25, No. 5, pp. 1077–1091
Publisher
Oxford University Press (OUP)
Publication Date
May 1, 2010
DOI
10.1359/jbmr.091114
ISSN
0884-0431