Who says “no” to participating in stroke clinical trials and why: an observational study from the Vancouver Stroke Program

BackgroundSuccessful stroke trials require adequate recruitment. In this observational study, we assessed reasons for refusal to provide informed consent in eligible patients approached for clinical trial participation at the Vancouver Stroke Program.MethodsWe assessed screening logs from four trials that were actively recruiting at our center: three randomized trials, two of which investigated different antithrombotic strategies for secondary …