Journal article
Single-Dose Mucosal Immunotherapy With Chimpanzee Adenovirus-Based Vaccine Accelerates Tuberculosis Disease Control and Limits Its Rebound After Antibiotic Cessation
Abstract
BACKGROUND: The development of strategies to accelerate disease resolution and shorten antibiotic therapy is imperative in curbing the global tuberculosis epidemic. Therapeutic application of novel vaccines adjunct to antibiotics represents such a strategy.
METHODS: By using a murine model of pulmonary tuberculosis (TB), we have investigated whether a single respiratory mucosal therapeutic delivery of a novel chimpanzee adenovirus-vectored …
Authors
Afkhami S; Lai R; D’agostino MR; Vaseghi-Shanjani M; Zganiacz A; Yao Y; Jeyanathan M; Xing Z
Journal
The Journal of Infectious Diseases, Vol. 220, No. 8, pp. 1355–1366
Publisher
Oxford University Press (OUP)
Publication Date
September 13, 2019
DOI
10.1093/infdis/jiz306
ISSN
0022-1899
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
AcyltransferasesAdenoviridaeAdministration, IntranasalAnimalsAntigens, BacterialAntitubercular AgentsCombined Modality TherapyDisease Models, AnimalFemaleGenetic VectorsHumansImmunization ScheduleInjections, IntramuscularMiceMycobacterium tuberculosisNasal MucosaPan troglodytesProof of Concept StudyTuberculosis VaccinesTuberculosis, PulmonaryVaccinationVaccines, Synthetic