Journal article
Ultrasensitive detection of oncogenic human papillomavirus in oropharyngeal tissue swabs
Abstract
BackgroundThe incidence of oropharyngeal squamous cell carcinoma (OPSCC) caused by oncogenic human papillomavirus (HPV) is rising worldwide. HPV-OPSCC is commonly diagnosed by RT-qPCR of HPV E6 and E7 oncoproteins or by p16 immunohistochemistry (IHC). Droplet digital PCR (ddPCR) has been recently reported as an ultra-sensitive and highly precise method of nucleic acid quantification for biomarker analysis. To validate the use of a minimally …
Authors
Isaac A; Kostiuk M; Zhang H; Lindsay C; Makki F; O’Connell DA; Harris JR; Cote DWJ; Seikaly H; Biron VL
Journal
Journal of Otolaryngology, Vol. 46, No. 1,
Publisher
SAGE Publications
Publication Date
January 2017
DOI
10.1186/s40463-016-0177-8
ISSN
1916-0208