Journal article
Prefrontal Cortex Dopamine Transporter Gene Network Moderates the Effect of Perinatal Hypoxic-Ischemic Conditions on Cognitive Flexibility and Brain Gray Matter Density in Children
Abstract
BACKGROUND: Genetic polymorphisms of the dopamine transporter gene (DAT1) and perinatal complications associated with poor oxygenation are risk factors for attentional problems in childhood and may show interactive effects.
METHODS: We created a novel expression-based polygenic risk score (ePRS) reflecting variations in the function of the DAT1 gene network (ePRS-DAT1) in the prefrontal cortex and explored the effects of its interaction with …
Authors
Miguel PM; Pereira LO; Barth B; de Mendonça Filho EJ; Pokhvisneva I; Nguyen TTT; Garg E; Razzolini BR; Koh DXP; Gallant H
Journal
Biological Psychiatry, Vol. 86, No. 8, pp. 621–630
Publisher
Elsevier
Publication Date
10 2019
DOI
10.1016/j.biopsych.2019.03.983
ISSN
0006-3223