A single-institution experience of salvage therapy for patients with early and locally advanced breast cancer who progress during neoadjuvant chemotherapy

PurposeProgression during neoadjuvant chemotherapy (NAT) for early and locally advanced breast cancer is generally uncommon. However, these patients tend to do poorly, and salvage therapy (ST) use is variable and often not well defined. We aimed to establish the characteristics and outcomes of breast cancer (BC) patients progressing on NAT, report the patterns of institutional ST usage, and identify predictors of ST failure.MethodsA …