Journal article
Prostaglandin E2 inhibits profibrotic function of human pulmonary fibroblasts by disrupting Ca2+ signaling
Abstract
We have shown that calcium (Ca2+) oscillations in human pulmonary fibroblasts (HPFs) contribute to profibrotic effects of transforming growth factor-β (TGF-β) and that disruption of these oscillations blunts features of pulmonary fibrosis. Prostaglandin E2 (PGE2) exerts antifibrotic effects in the lung, but the mechanisms for this action are not well defined. We thus sought to explore interactions between PGE2 and the profibrotic agent TGF-β in …
Authors
Mukherjee S; Sheng W; Michkov A; Sriarm K; Sun R; Dvorkin-Gheva A; Insel PA; Janssen LJ
Journal
American Journal of Physiology - Lung Cellular and Molecular Physiology, Vol. 316, No. 5, pp. l810–l821
Publisher
American Physiological Society
Publication Date
May 1, 2019
DOI
10.1152/ajplung.00403.2018
ISSN
1040-0605
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AgedAged, 80 and overCalcium SignalingCalcium-Calmodulin-Dependent Protein Kinase Type 2Cells, CulturedDinoprostoneExtracellular Signal-Regulated MAP KinasesFemaleFibroblastsGene Expression RegulationHumansLungMaleMiddle AgedProto-Oncogene Proteins c-aktPulmonary FibrosisReceptors, Prostaglandin E, EP2 SubtypeSmad2 ProteinTransforming Growth Factor beta