Journal article
The effect of membrane stabilizing agents on induction of the immune response. I. Effect of lymphocyte activation in mixed lymphocyte reactions.
Abstract
The effect of three membrane-stabilizing agents, chlorpromazine, imipramine, and lidocain, on in vitro activation of cellular responses was studied using the one-way MLR. Cellular activation was found to be depressed by these drugs. However, the degree of suppression paralleled the decline of viable cells in the cultures. It is concluded that drug-induced inhibition of MLR was due solely to the toxicity of the compounds.
Authors
Waterfield JD; Hammarström L; Smith E
Journal
Journal of Experimental Medicine, Vol. 144, No. 2, pp. 562–567
Publisher
Rockefeller University Press
Publication Date
August 1, 1976
DOI
10.1084/jem.144.2.562
ISSN
0022-1007