S-6 Novel interferon and interferon-independent signaling pathways

Primary cells such as fibroblasts rapidly respond to virus infection and extracellular dsRNA by making type I interferon, a pleiotropic cytokine with potent antiviral activity. The prototypic signaling pathways include recognition by members of the Toll-like receptor (TLR) and Retinoic acid-like receptor (RLR) families and subsequent activation of the transcription factor interferon regulatory factor 3 (IRF3). Production of IFNβ subsequently …