In Vitro Reversal of the Anti-Aggregant Effect of Ticagrelor Using Untreated Platelets

BACKGROUND:  Ticagrelor is an anti-platelet agent that is indicated for prevention of thrombosis after acute coronary syndrome or intra-coronary artery stent implantation, but it increases the risk of bleeding. Platelet transfusion has the potential to treat or prevent bleeding in patients taking ticagrelor, but the optimal quantity of platelets and timing of administration have not been fully defined. METHODS AND RESULTS:  Ten healthy subjects …