Transmission of Chromosomally Integrated HHV6 by Allogeneic Peripheral Blood Stem Cell Transplantation Associated with the Development of a Fatal Macrophage Activation (Haemophagocytic) Syndrome.

Abstract It is estimated that at least 1% of the UK population have chromosomal integration of HHV6 leading to persistently high levels of detectable viral DNA (Clark DA et al, JID2006: 193, p912–916). As far as we are aware transmission of integrated HHV6 by allogeneic stem cell transplantation has been described in the literature on only one previous occasion and this was not associated with disease (Clark DA et al, …