Abstract 548: Multistage nanoparticle delivery system for deep penetration into solid tumor

Abstract Background: Through the enhanced permeation and retention (EPR) effect, current FDA-approved cancer nanotherapeutics accumulate preferentially around leaky regions of the tumor vasculature due to their large size – typically ∼100 nm in diameter. However, these extravasated large nanocarriers localize mostly at the tumor periphery and might not be able to effectively distribute throughout the tumor due to the dense …