Journal article
A population-based study of the risk of osteoporosis and fracture with dutasteride and finasteride
Abstract
BackgroundDutasteride is a potent inhibitor of 5-alpha reductase enzymes that reduces concentrations of dihydrotestosterone to a greater extent than finasteride. Whether this has adverse implications for bone health is unknown. We compared the risk of osteoporosis and fractures in older men treated with dutasteride or finasteride.MethodsWe conducted a population-based retrospective cohort study with high-dimensional propensity score matching of …
Authors
Antoniou T; Macdonald EM; Yao Z; Gomes T; Tadrous M; Ho JM-W; Mamdani MM; Juurlink DN; for the Canadian Drug Safety and Effectiveness Research Network
Journal
BMC Musculoskeletal Disorders, Vol. 19, No. 1,
Publisher
Springer Nature
Publication Date
12 2018
DOI
10.1186/s12891-018-2076-9
ISSN
1471-2474