Amidicity Change as a Significant Driving Force and Thermodynamic Selection Rule of Transamidation Reactions. A Synergy between Experiment and Theory

Although essential in medicinal and industrial chemistry, transamidation reactions are still poorly understood mechanistically and in particular in terms of the extreme nature for their proceeding either very smoothly or not occurring at all. As yet, there exists no qualitative rule to predict the outcome of an amide interacting with an amine, with quantitative evaluations far from being established. In this paper we aim to clarify the …