Journal article
Membrane-Modulating Drugs can Affect the Size of Amyloid-β25–35 Aggregates in Anionic Membranes
Abstract
The formation of amyloid-β plaques is one of the hallmarks of Alzheimer’s disease. The presence of an amphiphatic cell membrane can accelerate the formation of amyloid-β aggregates, making it a potential druggable target to delay the progression of Alzheimer’s disease. We have prepared unsaturated anionic membranes made of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dimyristoyl-sn-glycero-3-phospho-L-serine (DMPS) and added …
Authors
Khondker A; Alsop RJ; Himbert S; Tang J; Shi A-C; Hitchcock AP; Rheinstädter MC
Journal
Scientific Reports, Vol. 8, No. 1,
Publisher
Springer Nature
DOI
10.1038/s41598-018-30431-8
ISSN
2045-2322