Journal article
Optical control of L-type Ca2+ channels using a diltiazem photoswitch
Abstract
L-type Ca2+ channels (LTCCs) play a crucial role in excitation–contraction coupling and release of hormones from secretory cells. They are targets of antihypertensive and antiarrhythmic drugs such as diltiazem. Here, we present a photoswitchable diltiazem, FHU-779, which can be used to reversibly block endogenous LTCCs by light. FHU-779 is as potent as diltiazem and can be used to place pancreatic β-cell function and cardiac activity under …
Authors
Fehrentz T; Huber FME; Hartrampf N; Bruegmann T; Frank JA; Fine NHF; Malan D; Danzl JG; Tikhonov DB; Sumser M
Journal
Nature Chemical Biology, Vol. 14, No. 8, pp. 764–767
Publisher
Springer Nature
Publication Date
August 2018
DOI
10.1038/s41589-018-0090-8
ISSN
1552-4450