Journal article
Statin toxicity from macrolide antibiotic coprescription: a population-based cohort study.
Abstract
BACKGROUND: Clarithromycin and erythromycin, but not azithromycin, inhibit cytochrome P450 isoenzyme 3A4 (CYP3A4), and inhibition increases blood concentrations of statins that are metabolized by CYP3A4.
OBJECTIVE: To measure the frequency of statin toxicity after coprescription of a statin with clarithromycin or erythromycin.
Authors
Patel AM; Shariff S; Bailey DG; Juurlink DN; Gandhi S; Mamdani M; Gomes T; Fleet J; Hwang YJ; Garg AX
Journal
Annals of Internal Medicine, Vol. 158, No. 12, pp. 869–876
Publisher
American College of Physicians
Publication Date
June 18, 2013
DOI
10.7326/0003-4819-158-12-201306180-00004
ISSN
1056-8751