Polypeptide models of collagen. Solution properties of (Gly‐Pro‐Sar)n and (Gly‐Sar‐Pro)n

Abstract Our studies on the solution conformation of (Gly‐Pro‐Sar) n and (Gly‐Sar‐Pro) n synthesized as polypeptide models for collagen are reported. It is found that, while (Gly‐Pro‐Sar) n exists in ordered triple‐helical conformation, (Gly‐Sar‐Pro) n remains as a disordered random coil in water. Addition of certain helix‐promoting solvents seems to generate order in (Gly‐Sar‐Pro) n .