Journal article
Protein kinase C α modulates liver X receptor α transactivation
Abstract
Liver X receptor alpha (LXRalpha), an oxysterol-activated nuclear hormone receptor, regulates the expression of genes involved in lipid and cholesterol homeostasis and inflammation. We show here that transactivation by LXRalpha in monkey kidney COS-1 (Cos-1) cells is decreased by activation of the protein kinase C (PKC) signaling pathway. In transient co-transfection assays, phorbol myristate acetate (PMA) suppressed LXR-dependent …
Authors
Delvecchio CJ; Capone JP
Journal
Journal of Endocrinology, Vol. 197, No. 1, pp. 121–130
Publisher
Bioscientifica
Publication Date
4 2008
DOI
10.1677/joe-07-0525
ISSN
0022-0795