Exercise Training Protects Against Overexposure to Glucocorticoids in Skeletal Muscle and Liver Tissue in the Fructose‐Fed Hamster

Elevated exposure to glucocorticoids (GC) in insulin target tissues has been linked to insulin resistance. Tissue exposure to GC is determined by both the receptor (GR) and the pre‐receptor enzyme, 11beta‐hydroxysteroid dehydrogenase type 1(11βHSD1), which converts inactive GC to the active form. We tested the hypothesis that beneficial effects of exercise are mediated through changes in the expression of 11βHSD1 and GR in skeletal muscle and …