Distinctive phenotypic, metabolic and contractile properties of Ins2Akita+/− and streptozotocin‐induced diabetic skeletal muscles.

The impact of type 1 diabetes on skeletal muscle (diabetic myopathy) during adolescence is largely unknown. Diabetic myopathy studies commonly use streptozotocin‐induced diabetic (STZ) rodents; however, streptozotocin has known detrimental effects on muscle cell growth. Here, we examined mechanisms of diabetic myopathy in adolescent Akita and STZ mice following 8 weeks of diabetes. Both models exhibited reduced muscle mass (Akita: 0.124 ± …