Journal article
Conformational Analysis of Free and Ca2+-bound forms of Verapamil and Methoxyverapamil
Abstract
In a recent experimental study (Tetreault, S. and Ananthanarayanan, V.S. (1993) J. Med. Chem. 36, 1324-1332) we showed that verapamil can bind Ca2+ in a nonpolar medium to form 1:1 and 2:1 drug:Ca2+ complexes and proposed that such complexes may represent the bioactive form of the drug. A similar suggestion has also been made earlier from theoretical considerations of the geometry of the drug (Zhorov, B. and Govyrin, V. (1983), Dokl.Akad.Nauk …
Authors
Zhorov BS; Ananthanarayanan VS
Journal
Journal of Biomolecular Structure and Dynamics, Vol. 11, No. 3, pp. 529–540
Publisher
Taylor & Francis
Publication Date
12 1993
DOI
10.1080/07391102.1993.10508013
ISSN
0739-1102