Journal article
Side chain flexibility and the pore dimensions in the GABAA receptor
Abstract
Permeation of ions through open channels and their accessibility to pore-targeting drugs depend on the pore cross-sectional dimensions, which are known only for static X-ray and cryo-EM structures. Here, we have built homology models of the closed, open and desensitized α1β2γ2 GABAA receptor (GABAAR). The models are based, respectively, on the X-ray structure of α3 glycine receptor (α3 GlyR), cryo-EM structure of α1 GlyR and X-ray structure of …
Authors
Rossokhin AV; Zhorov BS
Journal
Journal of Computer-Aided Molecular Design, Vol. 30, No. 7, pp. 559–567
Publisher
Springer Nature
Publication Date
7 2016
DOI
10.1007/s10822-016-9929-9
ISSN
0920-654X