The Effect of Increased Ventilation on Resistive Load Discrimination1–3

The ability of normal subjects to detect the addition of external resistive loads was determined both at rest and when ventilation was increased to more than 30 L/min by CO2 administration or exercise. Tidal volume, flow, and mouth and transpulmonary pressures were recorded during resistive load discrimination using standard psychophysical techniques. The mean resistance detection threshold was 0.40 +/- 0.06 cm H2O/L/s at rest, 0.36 cm H2O/L/s …