Journal article
CYP7A1, BAAT and UGT1A1 polymorphisms and susceptibility to anti-tuberculosis drug-induced hepatotoxicity
Abstract
SETTING: Evidence indicates that the polymorphisms in genes involved in bile acid metabolism may play an important role in the development of anti-tuberculosis drug-induced hepatotoxicity (ATDH) in tuberculosis (TB) patients treated with anti-tuberculosis drugs.
OBJECTIVE: To investigate the association between genetic variants of CYP7A1, BAAT and UGT1A1 and the risk of ATDH in a Chinese cohort.
Authors
Chen R; Wang J; Tang S-W; Zhang Y; Lv X-Z; Wu S-S; Yang Z-R; Xia Y-Y; Chen D-F; Zhan S-Y
Journal
The International Journal of Tuberculosis and Lung Disease, Vol. 20, No. 6, pp. 812–818
Publisher
International Union Against Tuberculosis and Lung Disease
Publication Date
6 2016
DOI
10.5588/ijtld.15.0450
ISSN
1027-3719
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
AdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedYoung AdultAcyltransferasesAntitubercular AgentsAsian PeopleBody Mass IndexCase-Control StudiesChemical and Drug Induced Liver InjuryCholesterol 7-alpha-HydroxylaseGenetic Predisposition to DiseaseGenotyping TechniquesGlucuronosyltransferaseLongitudinal StudiesPolymorphism, Single NucleotideProspective StudiesTuberculosis