Analysis of IL-6, STAT3 and HSPA1L Gene Polymorphisms in Anti-Tuberculosis Drug-Induced Hepatitis in a Nested Case-Control Study

Abstract

OBJECTIVES: To investigate the association of IL-6, STAT3 and HSPA1L polymorphisms with the risk of anti-tuberculosis drug-induced hepatitis (ATDH) in Chinese Han population. METHODS: The study was designed as a nested case-control study within a prospective cohort. Each case was matched with four controls by sex, age at baseline (±5 years), treatment history, disease severity, drug dosage and place of sample collection. Genetic polymorphisms …

Authors

Wang J; Chen R; Tang S; Lv X; Wu S; Zhang Y; Xia Y; Gao P; Tu D; Chen D

Journal

PLOS ONE, Vol. 10, No. 3,

Publisher

Public Library of Science (PLoS)

DOI

10.1371/journal.pone.0118862

ISSN

1932-6203

Associated Experts

Yuan Zhang

Assistant Professor (Part-Time), Faculty of Health Sciences

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