Journal article
Bivalent direct thrombin inhibitors: hirudin and bivalirudin
Abstract
Hirudin derivatives (e.g. lepirudin, desirudin) and hirudin analogues (e.g. bivalirudin) are bivalent direct thrombin inhibitors; that is, they bind to two distinct sites on thrombin-its active (catalytic) site and its fibrinogen-binding site (exosite 1). These bivalent binding properties contribute to their high affinity and high specificity for thrombin. This review compares the pharmacological properties of these agents, and describes …
Authors
Warkentin TE
Journal
Best Practice & Research Clinical Haematology, Vol. 17, No. 1, pp. 105–125
Publisher
Elsevier
Publication Date
3 2004
DOI
10.1016/j.beha.2004.02.002
ISSN
1521-6926