Journal article
Bivalirudin
Abstract
Bivalirudin is a direct thrombin inhibitor (DTI) frequently used for anticoagulation in the setting of invasive cardiology, particularly percutaneous coronary intervention (PCI). Bivalirudin has a unique pharmacologic profile: unlike other marketed DTIs, it undergoes predominant non-organ elimination (proteolysis), and has the shortest half-life (approximately 25 min). Its affinity for thrombin is intermediate between that of lepirudin …
Authors
Warkentin TE; Greinacher A; Koster A
Journal
Thrombosis and Haemostasis, Vol. 99, No. 05, pp. 830–839
Publisher
Thieme
Publication Date
2008
DOI
10.1160/th07-10-0644
ISSN
0340-6245
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Acute Coronary SyndromeAmino Acid SequenceAngioplasty, Balloon, CoronaryAnimalsAnticoagulantsBlood CoagulationCardiac Surgical ProceduresFibrinolytic AgentsHemorrhageHemostasis, SurgicalHeparinHirudinsHumansMolecular Sequence DataPeptide FragmentsPlatelet Aggregation InhibitorsPlatelet Glycoprotein GPIIb-IIIa ComplexRecombinant ProteinsThrombocytopeniaThrombosis