Journal article
Circulating Angiopoietin-2 as a Biomarker in ANCA-Associated Vasculitis
Abstract
The endothelial-specific Angiopoietin-Tie2 ligand-receptor system is an important regulator of endothelial activation. Binding of angiopoietin-2 (Ang-2) to Tie2 receptor renders the endothelial barrier responsive to pro-inflammatory cytokines. We previously showed that circulating Ang-2 correlated with disease severity in a small cohort of critically ill patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis. …
Authors
Monach PA; Kümpers P; Lukasz A; Tomasson G; Specks U; Stone JH; Cuthbertson D; Krischer J; Carette S; Ding L
Journal
PLOS ONE, Vol. 7, No. 1,
Publisher
Public Library of Science (PLoS)
Publication Date
2012
DOI
10.1371/journal.pone.0030197
ISSN
1932-6203