Journal article
Methacholine challenge tests to demonstrate therapeutic equivalence of terbutaline sulfate via different Turbuhaler® devices in patients with mild to moderate asthma: Appraisal of a four-way crossover design
Abstract
BACKGROUND/OBJECTIVE: To demonstrate therapeutic equivalence of terbutaline via two different Turbuhaler® devices by evaluating its protective effect against methacholine-induced bronchoconstriction in stable asthma.
METHODS: In this double-blind, double-dummy, multicentre, single-dose, 4-way crossover study, patients with stable mild-to-moderate asthma (FEV1 ≥80% predicted) were randomised to 0.5 or 1.5 mg terbutaline via either Turbuhaler® M2 …
Authors
Bjermer L; Gauvreau GM; Postma DS; O'Byrne PM; van den Berge M; Boulet L-P; Beckman O; Persson T; Román J; Carlholm M
Journal
Pulmonary Pharmacology & Therapeutics, Vol. 44, , pp. 1–6
Publisher
Elsevier
Publication Date
6 2017
DOI
10.1016/j.pupt.2017.02.004
ISSN
1094-5539
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Administration, InhalationAdolescentAdultAsthmaBronchial Provocation TestsBronchoconstrictionBronchoconstrictor AgentsBronchodilator AgentsCross-Over StudiesDose-Response Relationship, DrugDouble-Blind MethodEquipment DesignFemaleForced Expiratory VolumeHumansMaleMethacholine ChlorideMiddle AgedNebulizers and VaporizersTerbutalineYoung Adult