Journal article
Microbial Preparations (Probiotics) for the Prevention of Clostridium difficile Infection in Adults and Children: An Individual Patient Data Meta-analysis of 6,851 Participants
Abstract
OBJECTIVETo determine whether probiotic prophylaxes reduce the odds of Clostridium difficile infection (CDI) in adults and children.DESIGNIndividual participant data (IPD) meta-analysis of randomized controlled trials (RCTs), adjusting for risk factors.METHODSWe searched 6 databases and 11 grey literature sources from inception to April 2016. We identified 32 RCTs (n=8,713); among them, 18 RCTs provided IPD (n=6,851 participants) comparing …
Authors
Johnston BC; Lytvyn L; Lo CK-F; Allen SJ; Wang D; Szajewska H; Miller M; Ehrhardt S; Sampalis J; Duman DG
Journal
Infection Control and Hospital Epidemiology, Vol. 39, No. 7, pp. 771–781
Publisher
Cambridge University Press (CUP)
Publication Date
July 2018
DOI
10.1017/ice.2018.84
ISSN
0899-823X