Polygenic Contribution in Individuals With Early-Onset Coronary Artery Disease

BACKGROUND: Despite evidence of high heritability, monogenic disorders are identified in a minor fraction of individuals with early-onset coronary artery disease (EOCAD). We hypothesized that some individuals with EOCAD carry a high number of common genetic risk variants, with a combined effect similar to Mendelian forms of coronary artery disease, such as familial hypercholesterolemia. METHODS AND RESULTS: To confirm the polygenic contribution …