Journal article
Dopamine receptor modulation by a highly rigid spiro bicyclic peptidomimetic of Pro-Leu-Gly-NH2.
Abstract
A peptidomimetic analogue of Pro-Leu-Gly-NH2 (PLG), compound 3, has been synthesized that contains a highly constrained spiro bicyclic type-II beta-turn mimic. Peptidomimetic 3 enhanced the binding of the dopamine receptor agonist ADTN to dopamine receptors by 40% at 10(-6) M. At this same concentration PLG enhanced the binding of ADTN by 26%. Like PLG, 3 exhibited a bell-shaped dose-response curve with the maximum effect occurring at a …
Authors
Genin MJ; Mishra RK; Johnson RL
Journal
Journal of Medicinal Chemistry, Vol. 36, No. 22, pp. 3481–3483
Publisher
American Chemical Society (ACS)
Publication Date
October 1993
DOI
10.1021/jm00074a032
ISSN
0022-2623